Proton Beam Therapy-Based Computation in the Treatment of Human Ovarian and Liver Cancer using Srim

Authors

  • Joseph Omojola Department of Physics, Federal University of Lafia Author
  • Johnson Akinade Bamikole Department of Physics, Federal University of Lafia Author
  • Olodu Ali Federal University of Lafia Author

DOI:

https://doi.org/10.62050/ljsir2023.v1n1.166

Keywords:

Proton Beam Therapy, SRIM, Carcinoma

Abstract

Proton beam therapy is a promising technique used to cure various types of cancer diseases in the human body. This technique can selectively damage cancer cells while leaving surrounding cells unaffected thereby minimizing collateral damage to the healthy cells. The position and the width of the cancerous cells are determined to calculate the energy required to destroy the affected cells. The energy loss to the damaged cells and other body parts is calculated separately with high accuracy. Computational analysis indicates that proton beams with energies of 46 MeV, 47 MeV, and 48 MeV effectively destroy localized cancerous cells of the ovary from the epithelial cells to the more invasive cancerous growth while proton beam energy range of 50 MeV to 89 MeV should be considered for the treatment of liver cancer of both the periphery tumours and tumours in the hilum. Transport of ions in matter (TRIM) data shows that more than 80% of proton energy is given off during ion bombardment at Bragg’s peak, while the remaining percentage is lost by phonon production and by recoils.

Downloads

Download data is not yet available.

References

K. Giri, A. Khatiwada, and P. Bista, “SRIM as a Computational Tool to Study Energy Required During Prostate Cancer Treatment,” J. Nepal Phys. Soc., vol. 8, no. 1, pp. 48–54, Dec. 2022, https://doi.org/10.3126/jnphyssoc.v8i1.48285

S. Agarwal, Y. Lin, C. Li, R. E. Stoller, and S. J. Zinkle, “On the use of SRIM for calculating vacancy production: Quick calculation and full-cascade options,” Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. At., vol. 503, pp. 11–29, Sep. 2021, https://doi.org/10.1016/j.nimb.2021.06.018.

C. Zacharatou Jarlskog and H. Paganetti, “Physics Settings for Using the Geant4 Toolkit in Proton Therapy,” IEEE Trans. Nucl. Sci., vol. 55, no. 3, pp. 1018–1025, Jun. 2008, https://doi.org/10.1109/TNS.2008.922816.

S. J. Zinkle and L. L. Snead, “Opportunities and limitations for ion beams in radiation effects studies: Bridging critical gaps between charged particle and neutron irradiations,” Scr. Mater., vol. 143, pp. 154–160, Jan. 2018, https://doi.org/10.1016/j.scriptamat.2017.06.041.

R. E. Stoller, M. B. Toloczko, G. S. Was, A. G. Certain, S. Dwaraknath, and F. A. Garner, “On the use of SRIM for computing radiation damage exposure,” Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. At., vol. 310, pp. 75–80, Sep. 2013, https://doi.org/10.1016/j.nimb.2013.05.008

S. Chen and D. Bernard, “On the calculation of atomic displacements using damage energy,” Results Phys., vol. 16, p. 102835, Mar. 2020, https://doi.org/10.1016/j.rinp.2019.102835

C. S. Chung, T. I. Yock, K. Nelson, Y. Xu, N. L. Keating, and N. J. Tarbell, “Incidence of Second Malignancies Among Patients Treated With Proton Versus Photon Radiation,” Int. J. Radiat. Oncol., vol. 87, no. 1, pp. 46–52, Sep. 2013, https://doi.org/10.1016/j.ijrobp.2013.04.030

F. A. Cucinotta and M. Durante, “Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings,” Lancet Oncol., vol. 7, no. 5, pp. 431–435, May 2006, https://doi.org/10.1016/S1470-2045(06)70695-7

U. Saha, K. Devan, and S. Ganesan, “A study to compute integrated dpa for neutron and ion irradiation environments using SRIM-2013,” J. Nucl. Mater., vol. 503, pp. 30–41, May 2018, https://doi.org/10.1016/j.jnucmat.2018.02.039

N. Sekimura, Y. Kanzaki, S. R. Okada, T. Masuda, and S. Ishino, “Cascade damage formation in gold under self-ion irradiation,” J. Nucl. Mater., vol. 212–215, pp. 160–163, Sep. 1994, https://doi.org/10.1016/0022-3115(94)90048-5

Y. Uchinami et al., “A study on predicting cases that would benefit from proton beam therapy in primary liver tumors of less than or equal to 5 cm based on the estimated incidence of hepatic toxicity,” Clin. Transl. Radiat. Oncol., vol. 35, pp. 70–75, Jul. 2022, https://doi.org/10.1016/j.ctro.2022.05.004

J. F. Ziegler, “THE STOPPING AND RANGE OF IONS IN SOLIDS,” in Ion Implantation Science and Technology, Elsevier, 1984, pp. 51–108. https://doi.org/10.1016/B978-0-12-780620-4.50007-0

D. Seppelt et al., “Simple diameter measurement as predictor of liver volume and liver parenchymal disease,” Sci. Rep., vol. 12, no. 1, p. 1257, Jan. 2022, https://doi.org/10.1038/s41598-022-04825-8

D. C. Wolf, “94 Consistency of the Liver,” 1990

Y. S. Kim, “Human Tissues: Chemical Composition and Photon Dosimetry Data,” Radiat. Res., vol. 57, no. 1, p. 38, Jan. 1974, https://doi.org/10.2307/3573753

Y. S. Kim, “Human Tissues: Chemical Composition and Photon-Dosimetry Data. A Correction,” Radiat. Res., vol. 60, no. 2, p. 361, Nov. 1974, https://doi.org/10.2307/3573974

H. K. Graham, A. Eckersley, M. Ozols, K. T. Mellody, and M. J. Sherratt, “Human Skin: Composition, Structure and Visualisation Methods,” in Skin Biophysics, vol. 22, G. Limbert, Ed., in Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol. 22. , Cham: Springer International Publishing, 2019, pp. 1–18. https://doi.org/10.1007/978-3-030-13279-8_1

Y. Lee and K. Hwang, “Skin thickness of Korean adults,” 2001

O. Olatunji and D. B. Das, “Drug Delivery Using Microneedles,” in Comprehensive Biotechnology, Elsevier, 2011, pp. 625–642. https://doi.org/10.1016/B978-0-08-088504-9.00501-8

M. J. Norgett, M. T. Robinson, and I. M. Torrens, “A proposed method of calculating displacement dose rates,” Nucl. Eng. Des., vol. 33, no. 1, pp. 50–54, Aug. 1975, https://doi.org/10.1016/0029-5493(75)90035-7

N. M. Ghoniem and S. P. Chou, “Binary collision Monte Carlo simulations of cascades in polyatomic ceramics,” J. Nucl. Mater., vol. 155–157, pp. 1263–1267, Jul. 1988, https://doi.org/10.1016/0022-3115(88)90508-9

front

Downloads

Published

2023-12-29

How to Cite

Proton Beam Therapy-Based Computation in the Treatment of Human Ovarian and Liver Cancer using Srim. (2023). Lafia Journal of Scientific and Industrial Research, 1(1 & 2), 1-7. https://doi.org/10.62050/ljsir2023.v1n1.166

Most read articles by the same author(s)

1 2 3 4 5 > >>