Cluster of Differentiation 4, Serum Malondialdehyde and Immunoglobulin M concentrations in ageing of apparently healthy humans in Keffi, Nigeria

C. C. Nweze; M. Solomon; O. A. Nweze

المؤلفون

C. C. Nweze Department of Biochemistry and Molecular Biology, Nasarawa State University, Keffi, Nigeria 2Department of Biochemistry, University of Jos, Nigeria مؤلف
M. Solomon Department of Biochemistry and Molecular Biology, Nasarawa State University, Keffi, Nigeria 2Department of Biochemistry, University of Jos, Nigeria مؤلف
O. A. Nweze Department of Medicine and Surgery, College of Medicine, Chukwuemeka Odumegwu Ojukwu University,Awka, Nigeria مؤلف

الكلمات المفتاحية:

Cellular immunity، malondialdehyde، cluster of differentiation 4، Immunoglobulin M

الملخص

This study evaluated blood samples of 150 adults of age range 30-79 years with 96 males and 54 females on immunology indices; malondialdehyde (MDA), immunoglobin M (IgM) and cluster of differentiation 4 (CD+ 4). Serum MDA concentration significantly (p<0.05) increased with age. Serum MDA concentration of the males were significantly higher than the females. It indicates that the healthy ageing adult’s antioxidant/oxidant balance is compromised. Thus, the generation of reactive oxygen species (ROS) and ROS clearance has been disturbed and may result in oxidative damage to macromolecules in the cells. In all ages and gender, IgM antibodies to H. pylori was significantly (p<0.05) different and it increased with age. Study showed that IgM antibodies to H. Pylori was significantly (p<0,05) higher in males than females, thus higher level in elderly indicates an increase in autoimmune disease activity