Terrestrial Extremophiles as a Potential Source of Novel Antibiotics to  Combat Multi-Drug Resistant Pathogens

Auteur/ices

  • Adedotun Adefolalu
    Department of Biochemistry, Faculty of Life Sciences, Federal University Lafia, Nasarawa State, Nigeria; Federal University of Technology, Minna, Nigeria
  • Olukayode Orole
    Department of Microbiology, Faculty of Life Sciences, Federal University of Lafia, Nasarawa state, Nigeria
  • Oluwatosin Shittu
    Department of Biochemistry, Federal University of Technology, Minna, Nigeria
  • Evans Egwim
    Department of Biochemistry, Federal University of Technology, Minna, Nigeria
  • Peter Abioye
    Department of Microbiology, Federal University of Technology, Minna, Nigeria
  • Emmanuel Tope Oluwabusola
    Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, UK

Mots-clés :

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Résumé

Human and animal health are increasingly affected by multidrug-resistant pathogens despite efforts to address the challenge. Research focus, shifted to microorganisms from extreme environments as possible sources of antibiotics and metabolites to halt this menace of resistance in pathogens. This paper explores the rich collection of metabolites produced by these microorganisms, their environment, and their applications. Given their intricate nature, these organisms may harbor mechanisms for producing novel metabolites and antibiotics to combat multidrug-resistant pathogens. We highlight recent advances in the isolation, screening, and characterization of antibiotic-producing extremophiles from their harsh terrestrial environments. Studying the diverse chemical scaffolds and mechanisms of action in these microbes can inform the development of effective antimicrobials. Furthermore, we discuss the challenges and prospects of harnessing the vast array of terrestrial microorganisms in extreme environments to combat antibiotic resistance.

Dimensions

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cover

Publiée

2025-10-18

Comment citer

Terrestrial Extremophiles as a Potential Source of Novel Antibiotics to  Combat Multi-Drug Resistant Pathogens. (2025). Lafia Journal of Scientific and Industrial Research, 3(2), 165-177. https://doi.org/10.62050/ljsir2025.v3n2.778

Numéro

Volume 3, Issue 2 (October, 2025), Lafia Journal of Scientific and Industrial Research (LJSIR)

Rubrique

Life Sciences
Copyright & Licensing

Merci de créditer les auteurs lors de toute citation : Adedotun Adefolalu, Olukayode Orole, Oluwatosin Shittu, Peter Abioye, Evans Egwim, Emmanuel Oluwabusola (Author) (2025)

Creative Commons License

Ce travail est disponible sous licence Creative Commons Attribution - Partage dans les Mêmes Conditions 4.0 International.

Comment citer

Terrestrial Extremophiles as a Potential Source of Novel Antibiotics to  Combat Multi-Drug Resistant Pathogens. (2025). Lafia Journal of Scientific and Industrial Research, 3(2), 165-177. https://doi.org/10.62050/ljsir2025.v3n2.778

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